Publications

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Single-Cell Resolution Drug Effects of Renin-Angiotensin-Aldosterone Blockade in ZSF1 Rat Diabetic Kidney Disease
Balzer MS, Zhou J, Abedini A, Ma Z, Hou Y, Yadav T, Grundmann M, Pavkovic M, Susztak K
Journal of the American Society of Nephrology : JASN, 2026 Jan 7
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The Case | The sweet twirl-chorea as a diabetic complication: an elderly patient with CKD, hyperglycemia, and chorea
Schug AP, Ly LT, Eckardt KU, Balzer MS
Kidney international, 2026 Jan; 109(1): 235-236
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Expanding the Toolbox: Novel Urinary Biomarkers for Kidney Allograft Monitoring
Balzer MS, Parajuli S
Kidney360, 2025 Nov 1; 6(11): 1834-1836
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Nicotinamide nucleotide transhydrogenase deficiency and genetic susceptibility to high glucose-mediated peritoneal injury in mice
Ohse MC, Rong S, Schmidt S, Balzer MS, Nikolin C, von Vietinghoff S, Haller H, Schmidt-Ott KM, Kiyan Y, Shushakova N
Physiological reports, 2025 Nov; 13(22): e70642
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Analysis of individual patient pathway coordination in a cross-species single-cell kidney atlas
Klötzer KA, Abedini A, Li S, Balzer MS, Liang X, Levinsohn J, Ha E, Dumoulin B, Hogan JJ, Quinn G, Bloom RD, Schuller M, Eller K, Halmos B, Zhang NR, Susztak K
Nature genetics, 2025 Aug; 57(8): 1922-1934
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LAPTM5: A Novel Target in an Old Fight against Tubular Senescence
Balzer MS
Journal of the American Society of Nephrology : JASN, 2024 Dec 1; 35(12): 1624-1626
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Single-cell multi-omic and spatial profiling of human kidneys implicates the fibrotic microenvironment in kidney disease progression
Abedini A, Levinsohn J, Klötzer KA, Dumoulin B, Ma Z, Frederick J, Dhillon P, Balzer MS, Shrestha R, Liu H, Vitale S, Bergeson AM, Devalaraja-Narashimha K, Grandi P, Bhattacharyya T, Hu E, Pullen SS, Boustany-Kari CM, Guarnieri P, Karihaloo A, Traum D, Yan H, Coleman K, Palmer M, Sarov-Blat L, Morton L, Hunter CA, Kaestner KH, Li M, Susztak K
Nature genetics, 2024 Aug; 56(8): 1712-1724
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A comparative scRNAseq data analysis to match mouse models with human kidney disease at the molecular level
Abdank K, Cetin SZ, Abedini A, Susztak K, Eckardt KU, Balzer MS
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2024 May 31; 39(6): 1044-1047
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Single-cell transcriptomics and chromatin accessibility profiling elucidate the kidney-protective mechanism of mineralocorticoid receptor antagonists
Abedini A, Sánchez-Navaro A, Wu J, Klötzer KA, Ma Z, Poudel B, Doke T, Balzer MS, Frederick J, Cernecka H, Liu H, Liang X, Vitale S, Kolkhof P, Susztak K
The Journal of clinical investigation, 2024 Jan 2; 134(1)
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Endogenous renal adiponectin drives gluconeogenesis through enhancing pyruvate and fatty acid utilization
Onodera T, Wang MY, Rutkowski JM, Deja S, Chen S, Balzer MS, Kim DS, Sun X, An YA, Field BC, Lee C, Matsuo EI, Mizerska M, Sanjana I, Fujiwara N, Kusminski CM, Gordillo R, Gautron L, Marciano DK, Hu MC, Burgess SC, Susztak K, Moe OW, Scherer PE
Nature communications, 2023 Oct 17; 14(1): 6531
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Unified Mouse and Human Kidney Single-Cell Expression Atlas Reveal Commonalities and Differences in Disease States
Zhou J, Abedini A, Balzer MS, Shrestha R, Dhillon P, Liu H, Hu H, Susztak K
Journal of the American Society of Nephrology : JASN, 2023 Nov 1; 34(11): 1843-1862
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Treatment effects of soluble guanylate cyclase modulation on diabetic kidney disease at single-cell resolution
Balzer MS, Pavkovic M, Frederick J, Abedini A, Freyberger A, Vienenkötter J, Mathar I, Siudak K, Eitner F, Sandner P, Grundmann M, Susztak K
Cell reports. Medicine, 2023 Apr 18; 4(4): 100992
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Single-cell analysis highlights differences in druggable pathways underlying adaptive or fibrotic kidney regeneration
Balzer MS, Doke T, Yang YW, Aldridge DL, Hu H, Mai H, Mukhi D, Ma Z, Shrestha R, Palmer MB, Hunter CA, Susztak K
Nature communications, 2022 Jul 11; 13(1): 4018
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Single-cell analysis identifies the interaction of altered renal tubules with basophils orchestrating kidney fibrosis
Doke T, Abedini A, Aldridge DL, Yang YW, Park J, Hernandez CM, Balzer MS, Shrestra R, Coppock G, Rico JMI, Han SY, Kim J, Xin S, Piliponsky AM, Angelozzi M, Lefebvre V, Siracusa MC, Hunter CA, Susztak K
Nature immunology, 2022 Jun; 23(6): 947-959
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How Many Cell Types Are in the Kidney and What Do They Do?
Balzer MS, Rohacs T, Susztak K
Annual review of physiology, 2022 Feb 10; 84: 507-531
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Single cell biology-a Keystone Symposia report
Cable J, Elowitz MB, Domingos AI, Habib N, Itzkovitz S, Hamidzada H, Balzer MS, Yanai I, Liberali P, Whited J, Streets A, Cai L, Stergachis AB, Hong CKY, Keren L, Guilliams M, Alon U, Shalek AK, Hamel R, Pfau SJ, Raj A, Quake SR, Zhang NR, Fan J, Trapnell C, Wang B, Greenwald NF, Vento-Tormo R, Santos SDM, Spencer SL, Garcia HG, Arekatla G, Gaiti F, Arbel-Goren R, Rulands S, Junker JP, Klein AM, Morris SA, Murray JI, Galloway KE, Ratz M, Romeike M
Annals of the New York Academy of Sciences, 2021 Dec; 1506(1): 74-97
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Kidney toxicity of the BRAF-kinase inhibitor vemurafenib is driven by off-target ferrochelatase inhibition
Bai Y, Kim JY, Bisunke B, Jayne LA, Silvaroli JA, Balzer MS, Gandhi M, Huang KM, Sander V, Prosek J, Cianciolo RE, Baker SD, Sparreboom A, Jhaveri KD, Susztak K, Bajwa A, Pabla NS
Kidney international, 2021 Dec; 100(6): 1214-1226
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Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets
Miao Z, Balzer MS, Ma Z, Liu H, Wu J, Shrestha R, Aranyi T, Kwan A, Kondo A, Pontoglio M, Kim J, Li M, Kaestner KH, Susztak K
Nature communications, 2021 Apr 15; 12(1): 2277
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How to Get Started with Single Cell RNA Sequencing Data Analysis
Balzer MS, Ma Z, Zhou J, Abedini A, Susztak K
Journal of the American Society of Nephrology : JASN, 2021 Jun 1; 32(6): 1279-1292
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Urinary Single-Cell Profiling Captures the Cellular Diversity of the Kidney
Abedini A, Zhu YO, Chatterjee S, Halasz G, Devalaraja-Narashimha K, Shrestha R, S Balzer M, Park J, Zhou T, Ma Z, Sullivan KM, Hu H, Sheng X, Liu H, Wei Y, Boustany-Kari CM, Patel U, Almaani S, Palmer M, Townsend R, Blady S, Hogan J, Morton L, Susztak K, TRIDENT Study Investigators
Journal of the American Society of Nephrology : JASN, 2021 Mar; 32(3): 614-627
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The Nuclear Receptor ESRRA Protects from Kidney Disease by Coupling Metabolism and Differentiation
Dhillon P, Park J, Hurtado Del Pozo C, Li L, Doke T, Huang S, Zhao J, Kang HM, Shrestra R, Balzer MS, Chatterjee S, Prado P, Han SY, Liu H, Sheng X, Dierickx P, Batmanov K, Romero JP, Prósper F, Li M, Pei L, Kim J, Montserrat N, Susztak K
Cell metabolism, 2021 Feb 2; 33(2): 379-394.e8
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SGLT2 Inhibition by Intraperitoneal Dapagliflozin Mitigates Peritoneal Fibrosis and Ultrafiltration Failure in a Mouse Model of Chronic Peritoneal Exposure to High-Glucose Dialysate
Balzer MS, Rong S, Nordlohne J, Zemtsovski JD, Schmidt S, Stapel B, Bartosova M, von Vietinghoff S, Haller H, Schmitt CP, Shushakova N
Biomolecules, 2020 Nov 19; 10(11)
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Delayed non-myeloablative irradiation to induce long-term allograft acceptance in a large animal lung transplantation model
Hacker KS, Jansson K, Pichler J, Salman J, Avsar M, Siemeni T, Knöfel AK, Höffler K, Gottlieb J, Frühauf J, Werner M, Poyanmehr R, Jonigk D, Balzer MS, Hewicker-Trautwein M, Haverich A, Sommer W, Warnecke G
Transplant immunology, 2021 Apr; 65: 101350
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Molecular pathways in peritoneal fibrosis
Balzer MS
Cellular signalling, 2020 Nov; 75: 109778
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Peritoneal dialysate-range hypertonic glucose promotes T-cell IL-17 production that induces mesothelial inflammation
Helmke A, Hüsing AM, Gaedcke S, Brauns N, Balzer MS, Reinhardt M, Hiss M, Shushakova N, de Luca D, Prinz I, Haller H, von Vietinghoff S
European journal of immunology, 2021 Feb; 51(2): 354-367
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The interdependence of renal epithelial and endothelial metabolism and cell state
Balzer MS, Susztak K
Science signaling, 2020 Jun 9; 13(635)
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Soluble neprilysin, NT-proBNP, and growth differentiation factor-15 as biomarkers for heart failure in dialysis patients (SONGBIRD)
Claus R, Berliner D, Bavendiek U, Vodovar N, Lichtinghagen R, David S, Patecki M, Launay JM, Bauersachs J, Haller H, Hiss M, Balzer MS
Clinical research in cardiology : official journal of the German Cardiac Society, 2020 Aug; 109(8): 1035-1047
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Pretransplant dialysis modality and long-term patient and kidney allograft outcome: a 15-year retrospective single-centre cohort study
Balzer MS, Pankow S, Claus R, Dumann E, Ruben S, Haller H, Einecke G
Transplant international : official journal of the European Society for Organ Transplantation, 2020 Apr; 33(4): 376-390
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Patient Perspectives on Renal Replacement Therapy Modality Choice: A Multicenter Questionnaire Study on Bioethical Dimensions
Balzer MS, Clajus C, Eden G, Euteneuer F, Haller HG, Martin H, Patecki M, Schmitt R, Hiss M, Fuerholzer K
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis, 2019 Nov-Dec; 39(6): 519-526
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CX3CL1-CX3CR1 interaction mediates macrophage-mesothelial cross talk and promotes peritoneal fibrosis
Helmke A, Nordlohne J, Balzer MS, Dong L, Rong S, Hiss M, Shushakova N, Haller H, von Vietinghoff S
Kidney international, 2019 Jun; 95(6): 1405-1417
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Development of an Optimized LC-MS Method for the Detection of Specialized Pro-Resolving Mediators in Biological Samples
Kutzner L, Rund KM, Ostermann AI, Hartung NM, Galano JM, Balas L, Durand T, Balzer MS, David S, Schebb NH
Frontiers in pharmacology, 2019; 10: 169
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Are ISPD Guidelines on Peritonitis Diagnosis Too Narrow? A 15-Year Retrospective Single-Center Cohort Study on PD-Associated Peritonitis Accounting for Untrained Patients
Balzer MS, Claus R, Haller H, Hiss M
Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis, 2019 May-Jun; 39(3): 220-228
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Protein kinase C beta deficiency increases glucose-mediated peritoneal damage via M1 macrophage polarization and up-regulation of mesothelial protein kinase C alpha
Balzer MS, Helmke A, Ackermann M, Casper J, Dong L, Hiss M, Kiyan Y, Rong S, Timrott K, von Vietinghoff S, Wang L, Haller H, Shushakova N
Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, 2019 Jun 1; 34(6): 947-960
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Protein kinase C α inhibition prevents peritoneal damage in a mouse model of chronic peritoneal exposure to high-glucose dialysate
Wang L, Balzer MS, Rong S, Menne J, von Vietinghoff S, Dong L, Gueler F, Jang MS, Xu G, Timrott K, Tkachuk S, Hiss M, Haller H, Shushakova N
Kidney international, 2016 Jun; 89(6): 1253-67
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Oxaliplatin pharmacokinetics on hemodialysis in a patient with diffuse large B cell lymphoma
Balzer MS, Eggers H, Heuser M, Reising A, Bertram A
Annals of hematology, 2016 Mar; 95(4): 649-50
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Got Milk? Breastfeeding and Milk Analysis of a Mother on Chronic Hemodialysis
Balzer MS, Gross MM, Lichtinghagen R, Haller H, Schmitt R
PloS one, 2015; 10(11): e0143340
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On becoming a nephrologist: medical students' ideas to enhance interest in a career in nephrology
Patel AB, Balzer MS
American journal of kidney diseases : the official journal of the National Kidney Foundation, 2013 Sep; 62(3): 450-2

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